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Hybrid closed loop outpatient trial

The national Hybrid Closed-Loop Outpatient Trial is testing the use of an automated insulin delivery system to see if it is better at optimising blood glucose levels than standard therapy.

It includes 160 participants aged 12 to 25 and 120 adults aged 26 to 65 years. Recruitment for this trial is now closed.

The young people’s team is led by Perth Children's Hospital’s Professor Tim Jones, co-director of the Children’s Diabetes Centre, while Associate Professor David O’Neal, from Melbourne’s St Vincent’s Hospital, heads up the adult trial. 

Professor Jones said researchers wanted to understand how hybrid closed-loop systems affected the quality of life for young people living with type 1 diabetes, in addition to its potential savings to the healthcare system.

“The hybrid closed-loop system consists of an insulin pump, sensor with transmitter attached and a maths program (an algorithm) within the pump that automatically works out how much insulin is needed and is adjusted every five minutes,” Professor Jones said.

“This study will tell us if using an artificial pancreas is better than either insulin injections or normal insulin pump therapy at keeping blood glucose levels within the normal range. 

“Researchers will also explore how this technology affects how people feel about managing diabetes, specifically through improving their blood glucose levels, reducing diabetes complications and making treatment easier — which all goes towards reducing the burden of diabetes.”

The Hybrid Closed-Loop Outpatient Trial is a multi-centre study involving a number of Australian hospitals, and is funded by the Type 1 Diabetes Clinical Research Network, an innovative clinical research program led by JDRF Australia and funded by a Special Research Initiative through the Australian Research Council.

For more information, email diabetes.research@health.wa.gov.au

Advanced hybrid closed loop system

We are looking for young people with type 1 diabetes with a HbA1c above 9% to be involved in our new advanced hybrid closed loop system study.

Researchers want to see if using the system — MiniMed Medtronic 670G Advanced Hybrid Closed Loop — will improve blood glucose levels and HbA1c in this group.

To be in this study, you need to be:

  • Aged 12 – 25 years
  • Using an insulin pump already
  • Have your past two HbA1c above 9%

If you are interested in being involved and would like more information, please contact Julie Dart on 6456 4608 or julie.dart@health.wa.gov.au, or Dr Mary Abraham on 6456 5027 or mary.abraham@health.wa.gov.au.

For general inquiries including collaborations, please contact Senior Program Manager Tanyana Jackiewicz:

Phone: (08) 6456 4616
Email: diabetes.research@health.wa.gov.au

Postal address

Children's Diabetes Centre
Telethon Kids Institute
PO Box 855
West Perth Western Australia 6872
Australia