Skip to content

Identification of individual patterns of postprandial glycaemia in type 1 diabetes

Participants are needed for a new study looking at the patterns in glucose rise after meals.

The aim of this study — Identification of Individual Patterns of Postprandial Glycaemia in Type 1 Diabetes — is to find out whether we see similar patterns in the rise in glucose levels for a young person with diabetes for meals eaten at home and whether the pattern of glucose rise is different between people.

Research assistant Sabrina Binkowski said it was often a challenge for those with type 1 diabetes to work out how to deliver insulin to prevent glucose rising after a meal because the correct amount of insulin needed to be given at the right time to match the arrival of glucose into the blood.

“Recent clinical studies have found that people may differ in the time that insulin is needed,” she said.

“It has also been noted that the optimal timing of insulin delivery is quite consistent for each person after different meals.

“We hope the study will give us information that we can use to give each person individual advice to help reduce the rise in glucose levels after meals. This is opposed to giving everyone the same advice and finding that it doesn’t work well for some people.”  

We are looking for children aged eight to 15 years who have had type 1 diabetes for more than one year, have a HbA1C ≤ 9%, have been on multiple daily injections or a pump for more than six months and are currently using a CGM. Participants must also not have coeliac disease or any allergy that may prevent them from eating the test meal (Weetbix, milk and toast).

Most of this study will be conducted in your own home, and we will only require you to attend the Telethon Kids Institute for one initial visit.

For more information, please contact research assistant Sabrina Binkowski on 6456 4617 or Sabrina.Binkowski@health.wa.gov.au.

 

 

Linear carbohydrate study

People with diabetes work out how much insulin to give for meals based on how much carbohydrate they plan to eat and their insulin-to-carb ratio. This ratio is based on the idea that as the carbs amount increases, so does the insulin dose linearly.

Studies suggest that the relationship might not be linear and that a different ratio might decrease the risk of “hypos” and improve glucose levels after eating. We hope this study will help people with diabetes by giving more information on the best way to calculate their insulin doses before eating common carbohydrate meals.

If you participate in the study you will wear a Dexcom G4 sensor which tracks your blood glucose levels throughout the day. While wearing the sensor, you will give your insulin in your usual way and eat pancakes with maple syrup four mornings in a row. Each pancake meal is the same but the amount of carbohydrate in the meal changes from 20g up to 150g of carbohydrates.

After eating the pancakes you will be asked not to eat or exercise for the next five hours while you do normal activities such as going to school, work, reading, writing or watching movies. You can come to Perth Children's Hospital or the researcher can come to your home. The four study visits take approximately 30 minutes each.

We are looking for people who:

  • Are aged between 12-30 years
  • Have had T1DM for more than a year
  • Are on a pump or multiple daily injections with a HbA1c <8%
  • Are able to safely eat the study meals

If you are interested in participating or would like more information, email Natalie Cordon, natalie.cordon@health.wa.gov.au