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For general inquiries including collaborations, please contact Senior Program Manager Tanyana Jackiewicz:

Phone: (08) 6456 4616
Email: diabetes.research@health.wa.gov.au

Postal address

Children's Diabetes Centre
Telethon Kids Institute
PO Box 855
West Perth Western Australia 6872
Australia

Testing how much protein is needed to prevent overnight hypos which can happen after exercise

When people with type 1 diabetes exercise at moderate intensity (e.g. jogging, cycling and swimming) in the late afternoon, this can cause hypos when they are sleeping. We also know protein can raise blood glucose levels for a few hours after a meal.

We are now running a study to see how much protein is necessary to prevent overnight hypos without causing high blood glucose levels. This is an important study for two reasons: (1) it would be ideal if we can prevent hypos without causing high blood glucose levels, (2) taking protein after exercise is useful for both muscle building and post-exercise muscle repair.

In this study, you will perform 45 minutes of cycling on a stationary bike in the late afternoon at Perth Children's Hospital, and drink a protein drink at home, later in the night. You will do this on three different days. You will also wear a Dexcom G5 sensor for the study days, which we will provide if you are not currently using this system.

You are eligible for this study if you have type 1 diabetes, are aged 12-25 years old, have had diabetes for more than one year, with HbA1c <9%, and are otherwise healthy.

For more information, please contact Niru Paramalingam, Nirubasini.Paramalingam@health.wa.gov.au.

 

Dishabituation in patients with impaired hypoglycaemia awareness study

Young people are needed for a new study looking at ways to improve hypoglycaemia awareness through exercise.

“Usually people with type 1 diabetes produce hormones like adrenaline that gives them the pale and shaky feeling when they have a hypo and provides a warning that they need to treat the hypo,” study lead Dr Mary Abraham said.

“However, almost 20 to 25 per cent of patients with type 1 diabetes cannot tell when they are going low and this is called being hypo unaware. They get hypos frequently as their bodies produce less adrenaline leading to the development of an impaired awareness of hypoglycaemia.”

Dr Abraham said the study was based on the premise that impaired hypo awareness was an adaptive response of the body to repeated hypos.

“Previous studies have shown that a strong stimulus can restore the hormone response and reverse effects of this impaired awareness,” she said. “This process is called dishabituation.

“In the current study we are testing if people, who are hypo unaware, are able to restore the adrenaline response by introducing a single burst of high-intensity exercise.”

We are looking for children and young adults aged 14 years and older who have type 1 diabetes, a HbA1C ≤ 9 per cent who are interested in high-intensity exercise. 

For more information, please contact research assistant Joanne O’Dea via Joanne.O'Dea@health.wa.gov.au or email Dr Mary Abraham  Mary.Abraham@health.wa.gov.au.